Chronic hemolytic anemia due to cold agglutinins
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چکیده
منابع مشابه
Chronic hemolytic anemia due to cold agglutinins: the mechanism of resistance of red cells to C' hemolysis by cold agglutinins.
The red cells of patients with chronic hemolytic anemia due to cold agglutinins are agglutinated by antiglobulin serum in a nongamma reaction due to the coating of beta-globulins, C'4 and C'3. The red cells of such patients are abnormally resistant to C' hemolysis by cold agglutinin. Normal red cells can be made equally resistant to C' hemolysis by incubation with cold agglutinin and normal ser...
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A male, 47, developed chronic hemolytic anemia in association with hi9h titers of cold agglutinins in 1 966. His symptpm of the cold agglutinin syndrome began in 1 951 with cyanosis of the extremities nd face after exposure to cold. In 1 956, hemoglobinuna was first noted after chilling. In 1 962, the cold agglutinin titer was 1 : 1 6,000, and his red cells were coated with complement globulins...
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Erythrocytes obtained from patients who manifest autoimmune hemolytic anemia can be divided into at least three categories by the nature of their protein coats as determined by direct antiglobulin (Coombs) test: IgG alone, IgG and complement (C), C alone. IgG antibodies were detected by direct Coombs Test at 4#{176}Cbut not at 37#{176}Cin patients of type 3 A.H.A. Experiments at 4, 10, 15, 20, ...
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ژورنال
عنوان ژورنال: Journal of Clinical Investigation
سال: 1968
ISSN: 0021-9738
DOI: 10.1172/jci105764